Protein Research Department

Protein Research Department

The Protein Research Department (PRD) bundles cutting-edge research for a better understanding of cellular protein networks and forms around the DFG Collaborative Research Centers SFB 642 (spokesman: Klaus Gerwert) and SFB 480 (spokesman: Ulrich Kück). For the 19 projects, its Principle Investigators (PIs) are recruited from the faculties of Biology and Biotechnology, Chemistry and Biochemistry as well as Medicine and work within three areas: Sensory Biology (A), Platform Technologies in Protein Research (B), and Translation into Application (C). Under this umbrella, topics ranging from protein structure and mechanism, macromolecular assemblies, and functions of membrane-protein complexes up to cellular behaviour are studied from a molecular perspective using state of the art methods in structural biology, biophysics, biochemistry, and cell biology.
The PRD primarily targets at bridging the current gap between molecular and systemic approaches in protein research in order to achieve a molecular understanding of the cellular processes. Quantitative understanding of such complex and controlled biological processes at the cellular level requires a profound insight into the relationship between various genetically programmed and dynamically regulated networks. The PRD will focus on processes originating at, or involving biological membranes, exemplified by studies on sensory transduction originating at G-Protein Coupled receptors (GPCRs) and pathways involving GTP-binding proteins of the Ras superfamily. Since defects in the addressed interactions account for a variety of serious diseases, the acquired understanding at the atomic level should eventually result in the development of innovative biotechnology applications with long-term benefits for public health, e.g. tailored drugs for molecular therapy or the identification of biomarkers.




Protein Science in Bochum

Illustration of the different levels, on which biological processes are being studied within the PRD. The goal of this Research Department centers on bridging the gap between a detailled understanding of structure and function of single proteins in vitro as well as the rather qualitative understanding of protein interactions in protein networks in vivo, following this task both in „bottom-up“ and in „top-down“ approaches. This procedure allows firstly the identification of biomarkers for an early recognition of diseases, and secondly a directed intervention into disease-causing processes within molecular therapies.



News

Im Film: Protein Research Department stellt sich vor


Das Protein Research Department stellt sich und seine Arbeit filmisch vor.

Videoclip PRD


Olfactory receptor discovered in pigment cells of the skin


The team intends to examine the newly identified receptor in patients. A current study explains why. Researchers at Ruhr-Universität Bochum were the first ones to prove the existence of an olfactory receptor in pigment-producing cells in human skin, the so-called melanocytes. The team headed by Prof Dr Dr Dr habil. Hanns Hatt demonstrated that the violet-like scent Beta-Ionone can activate the receptor. Together with colleagues from Friedrich Schiller University Jena and the university hospital in Jena, the researchers at Bochum’s Department for Cellphysiology reported their findings in the Journal of Biological Chemistry.

Press article


Synthesis of hydrogen


Hydrogen is considered as a potential energy carrier of the future. However, its mass production remains problematic. Bochum-based researchers have found a new approach for a process suited for industrial applications. Researchers from Bochum have engineered a hydrogen-producing enzyme in the test tube that works as efficiently as the original. The protein – a so-called hydrogenase from green algae – is made up of a protein scaffold and a cofactor. The latter is the reaction centre where the substances that react with each other dock. When the researchers added various chemically synthesised substances to the protein scaffold, the cofactor spontaneously assembled.

Press article


Tag der offenen Türen auf dem Gesundheitscampus


Am 17. Juni 2016 von 13.00 bis 19.00 Uhr findet der „Tag der offenen Türen auf dem Gesundheitscampus“ in Bochum statt. Gemeinsam mit 19 Campus-Nachbarn, darunter der zukünftige Forschungsbau für molekulare Proteindiagnostik (ProDi), und -Partnern wird die Hochschule für Gesundheit (hsg) ein buntes und themenbezogenes Programm anbieten. Bochumer Bürgerinnen und Bürger, Familien, Nachbarn sowie Partner der Einrichtungen auf dem Gesundheitscampus sind herzlich willkommen.

Hochschule für Gesundheit