Protein Research Department

The Protein Research Department (PRD) bundles cutting-edge research for a better understanding of cellular protein networks and forms around the DFG Collaborative Research Centers SFB 642 (spokesman: Klaus Gerwert) and SFB 480 (spokesman: Ulrich Kück). For the 19 projects, its Principle Investigators (PIs) are recruited from the faculties of Biology and Biotechnology, Chemistry and Biochemistry as well as Medicine and work within three areas: Sensory Biology (A), Platform Technologies in Protein Research (B), and Translation into Application (C). Under this umbrella, topics ranging from protein structure and mechanism, macromolecular assemblies, and functions of membrane-protein complexes up to cellular behaviour are studied from a molecular perspective using state of the art methods in structural biology, biophysics, biochemistry, and cell biology.
The PRD primarily targets at bridging the current gap between molecular and systemic approaches in protein research in order to achieve a molecular understanding of the cellular processes. Quantitative understanding of such complex and controlled biological processes at the cellular level requires a profound insight into the relationship between various genetically programmed and dynamically regulated networks. The PRD will focus on processes originating at, or involving biological membranes, exemplified by studies on sensory transduction originating at G-Protein Coupled receptors (GPCRs) and pathways involving GTP-binding proteins of the Ras superfamily. Since defects in the addressed interactions account for a variety of serious diseases, the acquired understanding at the atomic level should eventually result in the development of innovative biotechnology applications with long-term benefits for public health, e.g. tailored drugs for molecular therapy or the identification of biomarkers.




Protein Science in Bochum

Illustration of the different levels, on which biological processes are being studied within the PRD. The goal of this Research Department centers on bridging the gap between a detailled understanding of structure and function of single proteins in vitro as well as the rather qualitative understanding of protein interactions in protein networks in vivo, following this task both in „bottom-up“ and in „top-down“ approaches. This procedure allows firstly the identification of biomarkers for an early recognition of diseases, and secondly a directed intervention into disease-causing processes within molecular therapies.



News

Im Film: Protein Research Department stellt sich vor


Das Protein Research Department stellt sich und seine Arbeit filmisch vor.

Videoclip PRD


Fehlerhafte Proteinfaltung als Alzheimer-Risikomarker


Der Marker zeigt bis zu 14 Jahre vor der klinischen Diagnose das Alzheimer-Risiko an. Der Nachweis einer fehlerhaften Faltung des Proteins Amyloid-Beta im Blut zeigt bei symptomfreien Menschen, die später tatsächlich Alzheimer entwickelten, ein deutlich erhöhtes Erkrankungsrisiko an – bis zu 14 Jahre vor der klinischen Diagnose der Demenz. Die Amyloid-Beta-Faltung erwies sich anderen untersuchten Risikomarkern als überlegen. Dies zeigten Wissenschaftler vom Deutschen Krebsforschungszentrum (DKFZ), von der RUB, vom Krebsregister des Saarlands und vom Netzwerk Alternsforschung der Universität Heidelberg.

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Wie Algen pinke Pigmente herstellen


Ein Enzym ist der Schlüssel zur Farbe bestimmter Algen. Und damit auch zu ihrer Fähigkeit zur Fotosynthese. Aus ein- und demselben Vorläufermolekül können Algen verschiedenfarbige Pigmente herstellen. Wie die Synthese des pinken Farbstoffs Phycoerythrobilin im Detail abläuft, konnte ein Team der Fakultät für Biologie und Biotechnologie der RUB und der Technischen Universität Kaiserslautern zeigen. Die Forscherinnen und Forscher fanden heraus, dass ein Schlüsselenzym die Bindung eines Substrats nur in einer unerwarteten Orientierung zulässt und somit für die entsprechende Farbe sorgt. Das Forschungsteam berichtet im Journal of Biological Chemistry vom 20. September 2019.

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